Wei Zhang


Projects as a member

  • A-CH4

    Optimal control of chemical reaction systems and application to drug resistance mitigating therapy

    Prof. Dr. Carsten Hartmann / Dr. Max von Kleist / PD Dr. Marcus Weber

    Project heads: Prof. Dr. Carsten Hartmann / Dr. Max von Kleist / PD Dr. Marcus Weber
    Project members: Wei Zhang
    Duration: 01.06.2014 - 31.05.2017
    Status: running
    Located at: Freie Universität Berlin


    Development and spread of drug resistant microorganisms is a major health issue which, accompanied by an attrition in drug development, is expected to worsen in the near future. The source of drug resistance development is the inadequate use of antimicrobials: Inadequate therapies insufficiently suppress susceptible strains, which may give rise to a drug resistant type. At the same time, inadequate therapy exerts enough selective pressure to provide the newly emerged resistant strain with a selective advantage that allows it to become fixed in the population. In recent years, we have elaborated the idea, that an optimal switching between existing antimicrobial drugs may mitigate drug resistance development in the individual. Drug resistance development is an intrinsically stochastic process. This process can be accurately described by the chemical master equation (CME). A major mathematical drawback is the fact that the CME cannot be solved directly due to its numerical complexity. Therefore, computation of an optimal control/therapy based on a direct numerical solution of the CME is usually not feasible. The aim of the proposed project is to mathematically characterize and develop optimal control policies derived from approximations of the CME, and to use the developed methods to suggest drug mitigating therapies to clinical partners in the field of HIV-1 and antibiotic resistance.


Projects as a guest